Figure 2.

Weight change (%) after the oral challenge with the AIEC strain LF82 (a). Fecal lipocalin-2 concentration (µg·g⁻¹ feces) at day 1 (D1) and D6 post-challenge (b), and correlation between lipocalin-2 concentration (µg·g⁻¹ feces) at D3 post-challenge and mean wheel running distance (km) per day (c) in the three groups. Intestinal permeability was assessed by measuring FITC-dextran 4 kDa in the serum 5 h after intragastric administration of 7.5 mg FITC-dextran (n = 16 mice/group) at week 12, before the AIEC challenge (d). Plasma concentration (ng·mL⁻¹) of active LPS 7 days post-AIEC pathobiont challenge (e). HFD-LS-O: pink triangles; HFD-LS-E green circles. * p < 0.05, **** p < 0.0001.