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Cytokine and bone-related protein release. Evaluation of pro-inflammatory growth factors, Interleukin 6 (IL6), Interleukin 1 beta (IL1β), Tumor Necrosis Factor alpha (TNFα) and main bone markers, Collagen alpha-1(I)chain (COLL1a1) and Alkaline Phosphatase (ALP) secreted by the 3D fracture models in the culture medium and assayed by immunoenzymatically tests after 3, 7, and 10 days of culture. Data are reported as mean±standard deviation (*: p < 0.05).
