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. 2022 Jun 5;11(11):1846. doi: 10.3390/cells11111846

Figure 1.

Figure 1

Lamina-associated domains (LADs) are dynamic features of peripheral chromatin architecture in senescence. (A) Chromatin association with the nuclear lamina via a LAD. LADs mostly harbor repressed genes, although occasional “escaper” regions contain expressed genes. While constitutive LADs (cLADs) are conserved during differentiation and between cell types, variable LADs (vLADs) are gained or lost; vLAD repositioning does not always concur with a change in gene expression. (B) Formation of SAHDs and SAHFs during replication-induced senescence (RIS) and oncogene-induced senescence (OIS). (C) Summary of aggregated profiles of LMNB1 and indicated histone modifications across LADs in normal cells and after OIS. (D) Speculative model of remodeling of nuclear lamina composition in OIS nuclei. Whereas loss of LMNB1 is documented, whether LMNA/C constitutes the main component of the lamina remains to be examined. OIS LADs are rich in H3K27me3 (see also panel B).