Figure 2.

Epigenetic reprogramming of large organized chromatin K9 modifications (LOCKs)/LADs in cancer cells. (A) Epigenetic alterations targeted to LOCKs upon TGFβ-induced epithelial-to-mesenchymal transition (EMT). (B) LOCKs/LADs, naturally enriched in H3K9me2 and DNA methylated (top), lose their heterochromatic states in cancer (bottom). What is still unclear is whether cancer cell LADs are actually H3K9me2 poor and DNA hypomethylated, and whether LOCKs/LADs losing H3K9me2 detach from the nuclear lamina (bottom right) or are retained at the lamina as euchromatic LADs (bottom left).