Table 1.
Distribution of the 17 study patients according to study group and baseline characteristics on day 0. Legend: SD, standard deviation; CRP, C-reactive protein; PaO2:FiO2, ratio of partial pressure of arterial oxygen (PaO2 in mmHg) to fractional inspired oxygen (FiO2%); COPD, chronic obstructive pulmonary disease; OSAS/OHS, obstructive sleep apnea syndrome/obesity-hypoventilation syndrome; LDH, lactate dehydrogenase; NIV, noninvasive ventilation group; IMV, invasive mechanical ventilation group. ° p-value of the Fisher’s exact test for dichotomous variables, Wilcoxon rank-sum test for numerical variables.
| NIV (n = 12) | IMV (n = 5) | p-Value ° | |
|---|---|---|---|
| Age, mean (SD) | 60.4 (10.2) | 69.0 (3.7) | 0.07 |
| Female sex, no. (%) | 5 (42.0) | 0 (0.0) | 0.24 |
| BMI ≥ 30 kg/m2, no. (%) | 27.7 (6.5) | 28.6 (2.8) | 1.00 |
| Ever smoker, no. (%) | 3 (25.0) | 3 (60.0) | 0.28 |
| Presence of major co-morbidities, no. (%) | 8 (66.7) | 5 (100.0) | 0.26 |
| Hypertension, no. (%) | 3 (25.0) | 1 (20.0) | 1.00 |
| Diabetes, no. (%) | 4 (33.3) | 2 (40.0) | 1.00 |
| Asthma/COPD, no. (%) | 1 (8.3) | 2 (40.0) | 0.19 |
| OSAS/OHS, no. (%) | 1 (8.3) | 2 (40.0) | 0.19 |
| Congestive heart failure, no. (%) | 0 (0.0) | 0 (0.0) | N/A |
| Ischemic cardiovascular disease, no. (%) | 0 (0.0) | 0 (0.0) | N/A |
| Chronic kidney disease, no. (%) | 1 (8.3) | 0 (0.0) | 1.00 |
| History of malignancy, no. (%) | 1 (8.3) | 1 (20.0) | 0.51 |
| PaO2:FiO2, mmHg, mean (SD) | 161.0 (46.09) | 112.9 (27.8) | 0.07 |
| CRP, mg/L, mean (SD) | 170.4 (39.5) | 187.4 (96.9) | 0.83 |
| D-dimer, ug/FEU/L, mean (SD) | 714.3 (264.6) | 580.0 (300.5) | 0.30 |
| LDH, U/L, mean (SD) | 339.7 (74.4) | 367.4 (81.9) | 0.53 |
| Lymphocyte count, mean (SD) | 902.2 (291.0) | 904.0 (381.2) | 0.83 |