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Forest plots and funnel plots for nephrotoxicity between colistin monotherapy and colistin plus meropenem combination therapy. Data regarding nephrotoxicity were reported in four studies including 535 patients (235 with colistin monotherapy, 300 with colistin plus meropenem combination therapy). There was no significant difference in nephrotoxicity between patients treated with colistin monotherapy and colistin plus meropenem combination therapy [24,25,31,32].
