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. 2022 May 28;23(11):6075. doi: 10.3390/ijms23116075

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Impact of EGCG on cancer-related signaling pathways. Components of ERK, PI3K-Akt, and 67-LR pathways (from right to left side of the image) are displayed. EGCG interference on ERK and PI3K-Akt pathways may depend on EGCG interaction with a receptor tyrosine kinase (RTK) or PTEN upregulation. EGCG binding to 67-LR may also induce acid sphingomyelinase (αSMase) activation and ceramide generation. See text in 2.1. subsection for a detailed description of the impacted signaling cascades and their implications. Red blunt arrows indicate negative regulation. Black arrows indicate positive regulation. Figure created with BioRender.com (accessed on 20 April 2022).