Table 3.
Examples of the cross-talk between the (endo)cannabinoid and angiotensin 1-7.
| Species | Model | Basal Treatment (Concentration (μM) or Dose) | Effect | Intervention (Concentration (μM) or Dose) | Influence on the Agonist Effect | Final Conclusion of the Authors | References |
|---|---|---|---|---|---|---|---|
| rats | ovariectomized pseudopregnant | steroid treatment and bolus of oil leading to decidualization |
uterus: ↓CB1Rs, ↑CB2Rs, ↔MAGL, ↓FAAH |
Ang 1-7 (24 μg/kg/h; i.u. for 5 days) |
uterus: ↑CB1Rs, ↑CB2Rs, ↑MAGL, ↔FAAH |
Ang 1-7 augments the expression of CB1Rs, CB2Rs, and MAGL in the decidualized uterus and thus may interfere with early events of decidualization | [92] |
| rats SHR WKY |
conscious (compounds microinjected into the PVN, doses in nmol/rat; if not stated otherwise) |
Ang 1-7 (0.03) or CP55940 (0.1) + AM251 3 μmol/kg i.v. |
both treatments: ↑BP stronger in SHR than in WKY | A-779 (3) AM251 (30) |
↓pressor effect of Ang 1-7 and CP55940 ↓pressor effect of Ang 1-7 |
mutual interaction in the PVN between the CB1Rs and the receptors for Ang 1-7 responsible for stimulation of the pressor response | [55] |
↓—decrease; ↑—increase; ↔—no change; Ang 1-7, angiotensin 1-7; BP, blood pressure; CB1R, cannabinoid receptor type 1; CB2R, cannabinoid receptor type 2; FAAH, fatty acid amide hydrolase; i.u., intrauterine; i.v., intravenous; MAGL, monoacylglycerol lipase; PVN, paraventricular nucleus of the hypothalamus; SHR, spontaneously hypertensive rats; WKY, Wistar Kyoto rats.