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Secondary BA biosynthesis. Primary BAs are initially deconjugated by BSH, which is encoded by most gut microbiota. Deconjugated CDCA is then converted to UDCA and by 7α- and 7β-HSDH expressed in different bacteria or LCA by multiple steps of catalytic reactions by Bai enzymes in Clostridium spp. Deconjugated CA is also converted to UCA by 7α- and 7β-HSDH or DCA by Bai enzymes.
