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. 2022 May 27;23(11):6046. doi: 10.3390/ijms23116046

Figure 3.

Figure 3

Protein structure of FXR. (A) General structure of nuclear receptors. A typical nuclear receptor consists of functional domains, such as activation of function 1 domain (AF1), DNA-binding domain (DBD), hinge region (H), ligand-binding domain (LBD), and activation of function 2 domain (AF-2). (B) Schematic representation of ligand-FXR-RXRα complex bound to IR1 element. Arrows indicate the inverted repeats of FXRE. Red pentagon and blue rhombus represent a bile acid molecule and an RXRα agonist, such as 9-cis-retinoic acid, respectively.