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. 2022 May 30;11(11):3094. doi: 10.3390/jcm11113094

Table 4.

Risk factors associated with the top ten symptoms one year after discharge.

Variables OR (95% CI) and p Values for Each Post Symptom
Fatigue Body Pain Shortness of Breath Chest Tightness Palpitations
age 1.00 (0.97, 1.03) 0.85 1.01 (0.99, 1.04) 0.38 0.99 (0.97, 1.01) 0.40 1.01 (0.97, 1.03) 0.89 1.00 (0.96, 1.03) 0.98
Sex, female 1.19 (0.55, 2.54) 0.66 1.36 (0.68, 2.74) 0.39 1.94 (1.01, 3.77) 0.04 1.75 (0.83, 3.68) 0.14 1.83 (0.83, 4.06) 0.14
smoking 0.68 (0.07, 6.33) 0.73 1.00 (0.19, 5.34) 1.00 3.56 (0.92, 13.83) 0.07 0.46 (0.05, 4.06) 0.49 NA NA
drinking 0.14 (0.02, 1.20) 0.07 0.74 (0.22, 2.48) 0.63 0.75 (0.26, 2.19) 0.60 1.10 (0.32, 3.79) 0.89 0.46 (0.09, 2.34) 0.35
Critically ill 0.71 (0.32, 1.56) 0.39 1.36 (0.70, 2.64) 0.36 0.81 (0.42, 1.53) 0.51 1.27 (0.63, 2.54) 0.50 1.05 (0.49, 2.28) 0.90
Hypertension 2.51 (1.08, 5.80) 0.03 0.97 (0.45, 2.11) 0.94 2.34 (1.16, 4.69) 0.02 1.28 (0.58, 2.81) 0.54 2.82 (1.26, 6.31) 0.01
Diabetes 0.86 (0.27, 2.68) 0.79 0.89 (0.30, 2.67) 0.84 0.56 (0.20, 1.61) 0.28 2.56 (0.97, 6.77) 0.06 3.22 (1.18, 8.81) 0.02
Other chronic diseases 0.78 (0.29, 2.12) 0.62 0.96 (0.42, 2.23) 0.93 0.96 (0.45, 2.04) 0.91 0.83 (0.34, 1.99) 0.46 1.31 (0.55, 3.12) 0.54
IL-8 2.40 (1.12, 5.17) 0.02 1.09 (0.53, 2.26) 0.82 0.79 (0.39, 1.60) 0.51 0.74 (0.33, 1.64) 0.46 0.35 (0.12, 1.00) 0.06
Variables OR (95% CI) and p Values for Each Post Symptom
Cough Expectoration Sore or Dry Throat Sleep Difficulties Anxiety
Age 0.99 (0.97, 1.02) 0.52 1.02 (0.99, 1.05) 0.12 0.99 (0.96, 1.02) 0.43 1.04 (1.01, 1.08) 0.02 0.99 (0.96, 1.03) 0.66
Sex, female 1.20 (0.61, 2.38) 0.60 0.56 (0.28, 1.12) 0.10 2.46 (1.21, 4.98) 0.01 2.52 (1.04, 6.11) 0.04 1.53 (0.37, 3.50) 0.32
Smoking 2.19 (0.53, 9.06) 0.28 2.53 (0.65, 9.84) 0.18 0.32 (0.04, 2.84) 0.31 0.96 (0.10, 9.22) 0.97 1.55 (0.27, 9.10) 0.63
Drinking 0.66 (0.21, 2.06) 0.47 0.75 (0.26, 2.13) 0.58 0.69 (0.20, 2.40) 0.56 1.81 (0.52, 6.33) 0.36 0.43 (0.09, 2.12) 0.30
Critically ill 0.78 (0.39, 1.55) 0.48 0.82 (0.41, 1.64) 0.57 0.78 (0.39, 1.53) 0.46 0.54 (0.23, 1.29) 0.16 0.93 (0.41, 2.08) 0.85
Hypertension 1.70 (0.81, 3.56) 0.16 2.08 (1.01, 4.30) 0.04 2.71 (1.30, 5.65) 0.01 0.81 (0.32, 2.04) 0.65 2.25 (0.96, 5.28) 0.06
Diabetes 1.25 (0.45, 3.43) 0.67 1.93 (0.71, 5.23) 0.20 0.85 (0.31, 2.36) 0.76 0.35 (0.07, 1.72) 0.20 1.78 (0.63, 5.02) 0.28
Other chronic diseases 0.63 (0.26, 1.49) 0.29 0.88 (0.38, 2.05) 0.77 1.28 (0.59, 2.80) 0.54 1.05 (0.38, 2.91) 0.92 1.37 (0.55, 3.42) 0.50
IL-8 0.74 (0.35, 1.57) 0.43 0.60 (0.27, 1.33) 0.21 0.88 (0.42, 1.83) 0.73 2.19 (0.98, 4.93) 0.06 1.18 (0.49, 2.80) 0.72

Notes: multivariable logistic regressions were used to estimate associated risk factors for post sequelae. NA: not applicable.