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Alterations in TRP metabolism and KYN metabolites may be an indication of exposure to environmental contaminants. Many environmental contaminants (i.e., PACs) are known to act as AhR ligands and are also known to regulate IDO and TDO expression, thereby affecting the production of immunomodulatory KYN metabolites. Moreover, many of these metabolites can also act as AhR ligands and induce AhR target genes. Figure created on biorender.com.
