Table 1. Demographic and clinical data on DBS subjects with available neuropsychological domains.
Data represent mean ± standard deviation, except number of individual (male/female). Trails A and B are T Scores in relation to age and education, and DRS2 attention and memory are scaled scores in relation to age and education. GDS is the number of symptoms endorsed out of 30. DRS2 attention and memory are subscores of the same test so the individuals completing these tests are the same. Post-DBS score was obtained 3 months after DBS. Abbreviations: Dementia Rating Scale-2 (DRS), Geriatric Depression Scale (GDS), Levodopa equivalent daily dose (LEDD), Mini-Mental Status Examination (MMSE).
| Available data on cognitive domains of interest | |||||
|---|---|---|---|---|---|
| Domain of interest | Psychomotor speed | Executive Function | Attention | Memory | Depression |
| Demographics | |||||
| No. of individuals (M/F) | 26 (19/7) | 25 (18/7) | 20 (14/6) | 20 (14/6) | 16 (13/3) |
| Age (yrs) | 68.0 ± 8.7 | 67.9 ± 9.0 | 72.0 ± 6.5 | 72.0 ± 6.5 | 73.9 ± 5.0 |
| Education (yrs) | 13.9 ± 3.2 | 14.2 ± 2.8 | 13.5 ± 3.4 | 13.5 ± 3.4 | 13.6 ± 2.7 |
| Disease information | |||||
| Disease duration (yrs) | 9.6 ± 5.5 | 9.2 ± 5.2 | 9.3 ± 5.7 | 9.3 ± 5.7 | 8.0 ± 4.0 |
| LEDD (mg) | 733 ± 384 | 733 ± 392 | 716 ± 364 | 716 ± 364 | 790 ± 429 |
| MMSE preDBS | 27.8 ± 1.7 | 27.8 ± 1.7 | 27.4 ± 1.8 | 27.4 ± 1.8 | 27.1 ± 1.8 |
| Neuropsychological test (change pre-DBS and 3m post-DBS) | Trails A | Trails B | DRS2-attention | DRS2-memory | GDS |
| Pre-DBS Score | 47.0 ± 10.9 | 45.0 ± 16.4 | 11.3 ± 2.1 | 8.7 ± 2.6 | 8.2 ± 6.1 |
| Post-DBS Score | 42.8 ± 10.1 | 38.2 ± 21.0 | 12.0 ± 2.0 | 8.2 ± 3.7 | 7.5 ± 6.1 |
| Δ in Test Score | −4.2 ± 9.8 =Worsened |
−6.7 ± 12.1 =Worsened |
0.70 ± 2.3 =Improved |
−0.5 ± 4.8 =Worsened |
−0.62 ± 7.4 =Improved |