. Author manuscript; available in PMC: 2022 Jun 9.

Published in final edited form as: J Parkinsons Dis. 2022;12(3):851–863. doi: 10.3233/JPD-212833

Table 2. Value of pre-DBS clinical and/or MRI metric in predicting DBS outcomes.

Model significance was assessed using R² and p-values from the fitted linear models. The significance of value added by MRI was calculated from the F-statistic of an ANOVA comparing the full model (Model C) and clinic only model (Model A). Italicized bold text indicates significance (<0.05) with False Discovery Rate correction.

Domain	Psychomotor speed	Executive function	Attention	Memory	Depression
Model A: Clinical information only
R²	0.282	0.186	0.460	0.504	0.667
p-value	*0.005*	0.104	0.044	*0.009*	*0.002*

Model B: MRI information only
R²	0.181	0.321	0.148	0.186	0.179
p-value	0.030	0.087	0.094	0.058	0.449

Model C: Clinic + MRI information
R²	0.373	0.605	0.642	0.584	0.778
p-value	*0.005*	*0.005*	*0.008*	*0.007*	*0.008*

Value added by MRI over clinic (C vs. A)
R²	0.091	0.455	0.182	0.080	0.111
p-value	0.081	*0.008*	*0.018*	0.109	0.236