Table 3. Full Model (Model C) best clinical and MRI metrics identified using penalized regression in predicting DBS outcomes.
Each set of predictors as determined by elastic net was fit to an ordinary least squares model.
| Domain | Psychomotor Speed | Executive function | Attention | Memory | Depression |
|---|---|---|---|---|---|
| Clinical information | |||||
| Age | * | * | + | + | |
| Sex | + | + | |||
| Disease Duration | + | + | + | ||
| Education | |||||
| Pre-DBS test score | * | * | * | ** | |
| Substantia Nigra (SN) | |||||
| SNc | + | + | |||
| SNr | |||||
| Striatal and other basal ganglia structures | |||||
| Putamen | * | ||||
| Caudate | + | * | + | ||
| GP | + | ||||
| STN | + | ||||
| Limbic structures | |||||
| Amygdala | |||||
| Hippocampus | ** | + | |||
| NAcc | |||||
| Other association structures | |||||
| Thalamus | |||||
| Red nucleus | |||||
+
identified by penalized regression analysis but individual prediction significance was >0.05
*
metric significance was between 0.05 and 0.01
**
metric significance was <0.01.
Abbreviations: Globus pallidus (GP), Nucleus accumbens (NAcc), Substantia nigra pars compacta (SNc), Substantia nigra pars reticulata (SNr), Subthalamic nucleus (STN).