Table 4.
Comparison of animal models of schizophrenia.
| Model | Positive Symptoms | Negative Symptoms | Cognitive Symptoms | Progress of Schizophrenia | Role of Proteins | Time-Consuming | The Degree of Difficulty in Making the Model | Expense |
|---|---|---|---|---|---|---|---|---|
| Amphetamine model | + | − | + | − | − | − | low | low |
| 6-OHDA model | − | + | + | + | − | + | high | low |
| DOI model | + | − | + | − | − | − | low | low |
| PCP model | + | + | + | − | − | − | low | low |
| Ketamine model | + | + | + | − | − | − | low | low |
| MK-801 model | + | + | + | − | − | − | low | low |
| DISC-1 model | − | + | + | − | + | + | high | high |
| 22q11.2 deletion | + | + | + | − | + | + | high | high |
| Dysbindin-1 model | − | + | + | − | + | + | high | high |
| NGR1 model | + | − | + | − | + | + | high | high |
| NVHL model | + | + | + | + | − | + | high | low |
| MIA model | + | + | + | + | − | + | low | low |
| MAM model | + | + | + | + | − | + | low | low |