Figure 1.

The lncRNAs involved in the sequential stages of developing neurons. The scheme illustrates three ideal key stages in the commitment/differentiation of developing neurons, from stem cells (left) to neural progenitor cell (middle) and to postmitotic differentiating neuron (right). At the bottom, a few representative lncRNAs are reported for each stage, with an indication of the intracellular function or process in which it has been involved. lncRNAs with a possible implication in NDD pathogenesis are reported in bold; the up and down arrows indicate, respectively, increased and reduced expression of lncRNAs in post-mortem biopsies or models of NDD.