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. 2009 Nov 26;13(8b):2189–2199. doi: 10.1111/j.1582-4934.2008.00673.x

Figure 5.

Figure 5

The anti‐apoptotic effect of strontium ranelate (SrRan) is mediated by PI3K Akt signalling in osteoblasts. (A, B) Osteoblasts from [CaSR+/+] and [CaSR−/−] mice were cultured in DMEM supplemented with 10% FCS or 1% FCS for 24 hrs and treated with or without SrRan for 24 hrs. Effector caspases activity was determined and the results are expressed as treated over control ratio (T/C) (mean ± SD). * indicates a significant difference with the 1% FCS control group (P<0.05). (C, D) Osteoblasts from [CaSR+/+] and [CaSR−/−] mice were cultured in DMEM supplemented with 1% FCS, for 24 hrs, treated with or without SrRan (3 mM) for 24 hrs in the presence or absence of the PI3K inhibitor wormanin (10 mM), and effector caspases activity was determined. Results are expressed as mean ± SD (n= 6). a and b indicate a significant difference with the 1% FCS and SrRan groups, respectively (P < 0.05).