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. 2022 May 28;23(11):6079. doi: 10.3390/ijms23116079

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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fMRI imaging. (A) BOLD effect in MRI. (B) Areas of decreased fMRI task-induced deactivation in posteromedial cortical areas in patients with AD compared to older controls. Adapted from [67] with permission from Hindawi. (C) Spatial maps of resting-state networks (RSNs, transparent yellow) overlaid with clusters showing significantly lower (red) or higher (blue) functional connectivity in AD compared to control subjects (CTR). Adapted from [76] with permission from BMJ Publishing Group Ltd. (D) Right hippocampal connectivity maps in the healthy age-matched control group (top row) and AD group (bottom row). Adapted from [77] with permission from Elsevier.