. 2022 May 28;11(11):3056. doi: 10.3390/jcm11113056

Table 4.

Correlation of age and sex with subjective symptoms and lipid-associated parameters.

Correlations		Age				Sex
		Type 1	Type 2	Type 3	Type 4	Type 1	Type 2	Type3	Type 4
Symptom scores
SPEED	r_s=	−0.153	0.146	−0.238	−0.094	−0.137	0.003	−0.004	−0.045
SPEED	p=	0.001	0.108	<0.001	0.034	0.002	0.975	0.948	0.313
SPEED (Frequency)	r_s=	−0.140	0.168	−0.191	−0.080	−0.138	−0.033	−0.018	−0.084
SPEED (Frequency)	p=	0.002	0.064	0.001	0.070	0.002	0.717	0.746	0.059
SPEED (Severity)	r_s=	−0.146	0.120	−0.253	−0.094	−0.120	0.031	0.008	−0.012
SPEED (Severity)	p=	0.001	0.187	<0.001	0.034	0.007	0.731	0.882	0.796
OSDI	r_s=	0.045	0.106	−0.035	0.088	−0.217	−0.090	−0.084	−0.126
OSDI	p=	0.317	0.244	0.535	0.049	<0.001	0.324	0.136	0.004
OSDI (Frequency)	r_s=	0.115	0.165	0.008	0.158	−0.192	−0.046	−0.094	−0.160
OSDI (Frequency)	p=	0.010	0.067	0.886	<0.001	<0.001	0.612	0.094	<0.001
OSDI (Activity limitation)	r_s=	−0.088	0.028	−0.095	−0.062	−0.073	0.056	0.071	0.026
OSDI (Activity limitation)	p=	0.049	0.761	0.093	0.162	0.104	0.538	0.206	0.558
OSDI (Environment)	r_s=	−0.149	−0.014	−0.133	−0.111	−0.169	−0.178	−0.085	−0.100
OSDI (Environment)	p=	0.001	0.878	0.018	0.012	<0.001	0.049	0.131	0.025
Lipid-associated parameters
LLT	r_s=	0.126	−0.004	−0.016	0.173	−0.107	−0.152	0.120	−0.091
	p=	0.005	0.964	0.784	<0.001	0.017	0.093	0.034	0.041
MGE	r_s=	−0.136	−0.044	−0.087	−0.167	−0.011	−0.047	0.021	−0.032
	p=	0.002	0.632	0.121	<0.001	0.806	0.605	0.712	0.468
MGE (upper)	r_s=	−0.107	−0.093	−0.050	−0.148	−0.095	−0.022	0.028	−0.078
	p=	0.017	0.305	0.378	0.001	0.034	0.810	0.622	0.078
MGE (lower)	r_s=	−0.109	0.033	−0.089	−0.122	0.087	−0.056	0.005	0.031
	p=	0.015	0.715	0.115	0.006	0.053	0.535	0.932	0.485
meiboscale	r_s=	0.263	0.295	0.194	0.275	−0.001	0.083	−0.074	−0.041
	p=	<0.001	0.001	0.001	<0.001	0.983	0.368	0.199	0.363
Meiboscale (upper)	r_s=	0.301	0.380	0.266	0.312	0.025	0.052	−0.067	−0.018
	p=	<0.001	<0.001	<0.001	<0.001	0.582	0.567	0.238	0.694
Meiboscale (lower)	r_s=	0.155	0.145	0.057	0.151	−0.020	0.085	−0.083	−0.034
	p=	0.001	0.110	0.316	0.001	0.652	0.350	0.140	0.449
Blink and other tear parameters
Schirmer	r_s=	−0.138	−0.268	0.011	−0.034	−0.002	0.195	−0.076	0.027
	p=	0.002	0.003	0.840	0.438	0.962	0.031	0.179	0.539
TB	r_s=	−0.191	−0.171	−0.186	−0.127	−0.035	−0.001	−0.095	−0.125
	p=	<0.001	0.058	0.001	0.004	0.442	0.993	0.091	0.005
PB	r_s=	−0.212	−0.234	−0.142	−0.169	−0.070	−0.150	−0.037	−0.077
	p=	<0.001	0.009	0.011	<0.001	0.117	0.098	0.512	0.084
PB rate (%)	r_s=	−0.176	−0.124	−0.024	−0.134	−0.026	−0.046	0.024	−0.012
	p=	<0.001	0.175	0.672	0.003	0.568	0.613	0.667	0.786
FTBUT	r_s=	−0.208	−0.007	−0.030	−0.043	0.100	0.020	0.044	0.021
	p=	<0.001	0.937	0.592	0.333	0.026	0.824	0.433	0.631
SPK	r_s=	0.134	0.048	−0.027	−0.001	−0.080	0.103	−0.128	−0.130
	p=	0.003	0.602	0.634	0.981	0.077	0.263	0.024	0.003

LLT: average lipid-layer thickness; MGE: number of expressible meibomian glands; TB: number of total blinks; PB: number of partial blinks; PB (%): partial blink rate; FTBUT: fluorescein tear-film break-up time; SPK: superficial punctate keratitis; p: statistically significant by Spearman’s rank correlation.