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. 2022 May 27;23(11):6010. doi: 10.3390/ijms23116010

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Functionalization strategies of hydrogels with secretome (total or only EVs) for treatment of cartilage damage. Secretomes, composed of soluble factors, as growth factors (GF), and extracellular vesicles (EVs) (microvesicles (MVs) and exosomes (EXO)), can be directly associated with hydrogel (with crosslinkers or not, (a,b)) or to be initially encapsulated and then incorporated with the hydrogel (c). The images were obtained from Servier Medical Art (http://smart.servier.com/, Accessed on 7 April 2022), licensed under a Creative Commons Attribution 3.0 Unported License.