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(A) Chemical structure of the velcrin-type of MG compounds; (B) DNMDP-mediated PDE3A–SLFN12 heterotetramer formation models; (C) a cartoon model for elucidating the velcrin compound-induced mechanism of action for inducing cell death; (D) summary of the structure–activity relationship (SAR) of representative anagrelide analogs for deriving the lead compound A6. (D) is adapted from an original publication by Chen et al. [33].
