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(A) Chemical structure of AN1, AN2, 10O5, and 8F20 as MG compounds; (B) a cartoon model to show the key finding for disease treatment. Such types of MG discovered by the logically designed assay could only ligate LC3 to mHTT but not wtHTT. Thus, mHTT could be glued on LC3 for degradation of mHTT but not wtHTT by autophagy.
