Table 1.

Relationship of MGs with their recruited protein substrates using CRL4^CRBN *.

MG Compounds	Neosubstrates/ Protein Targets		Neosubstrates/ Protein Targets	Molecular Glue (MG) Compounds
Thalidomide	IKZF1 #, IKZF3, ZNF692, ZNF276, SALL4, RNF166, ZBTB16, FAM83F, p63		IKZF1	thalidomide, lenalidomide, pomalidomide, avadomide/CC-122, FPFT-2216, iberdomide/CC-220, CC-3060, CC-92480, CC-885
Lenalidomide (Revlimid)	IKZF1, IKZF3, ZFP91, ZFP692, ZNF276, ZNF653, ZNF827, SALL4, RNF166, WIZ1, CK1α, FAM83F, RAB28		IKZF3	thalidomide, lenalidomide, pomalidomide, avadomide/CC-122, iberdomide/CC-220, 92480, CC-885
Pomalidomide	IKZF1, IKZF3, ZFP91, ZFP692, ZNF276, ZNF653, ZNF827, SALL4, RNF166, GZF1, ZBTB39, ZNF98, WIZ1, ZBTB16, FAM83F, RAB28, DTWD1		ZNF692	thalidomide, lenalidomide, pomalidomide,
Avadomide (CC-122)	IKZF1, IKZF3, ZFP91		ZNF276	thalidomide, lenalidomide, pomalidomide,
5-hydroxy-thalidomide	SALL4, ZBTB16		SALL4	thalidomide, lenalidomide, pomalidomide, FPFT-2216,
FPFT-2216	IKZF1, CK1α		RNF166	thalidomide, lenalidomide, pomalidomide,
Iberdomide (CC-220)	IKZF1, IKZF3, ZFP91, ZNF98		ZBTB16	thalidomide, pomalidomide, 5-hydroxythalidomide, CC-647, CC-3060
CC-647	ZBTB16		FAM83F	thalidomide, lenalidomide, pomalidomide,
CC-3060	ZBTB16, IKZF1, ZFP91, ZNF276		p63	thalidomide
CC-92480	IKZF1, IKZF3		ZFP91	lenalidomide, pomalidomide, avadomide/CC-122, iberdomide/CC-220, CC-3060
CC-885	IKZF1, IKZF3, GSPT1, CK1α, PLK1, HBS1L		ZNF653	lenalidomide, pomalidomide,
CC-90009	GSPT1		ZNF827	lenalidomide, pomalidomide,
ZXH-1-161	GSPT1, GSPT2		WIZ1	thalidomide, lenalidomide,
			CK1α	lenalidomide, FPFT-2216, CC-885
			RAB28	lenalidomide, pomalidomide,
			GZF1	pomalidomide,
			ZBTB39	pomalidomide,
			ZNF98	pomalidomide, iberdomide/CC-220,
			DTWD1	pomalidomide,
			ZNF276	CC-3060
			GSPT1	CC-885, CC-90009, ZXH-1-161
			PLK1	CC-885
			HBS1L	CC-885
			GSPT2	ZXH-1-161

* Table 1 data summary is based on the review article written recently by Kozicka and Thoma [12]. ^# Abbreviations: CK1α, casein kinase 1α; DTWD1, DTW domain-containing protein 1; FAM83F, family with sequence similarity 83, member F; GSPT1, G1-to-S phase transition 1; GZF1, GDNF-inducible zinc-finger protein 1; HBS1L, HBS1-like translational GTPase; IKZF1, IKAROS family zinc-finger protein 1; PLK1, polo-like kinase 1; RAB28, Ras-associated protein Rab28; RNF166, ring-finger protein 166; SALL4, Sal-like protein 4; WIZ1, widely interspaced zinc-finger protein 1; ZBTB16, zinc-finger and BTB domain-containing protein 16; ZFP91, zinc-finger protein 91; ZNF692, zinc-finger protein 692.