Key Points	References
Necroptosis is characterized by the necrosome formation;	[12,127,130,131,132,133]
RIPK3, RIPK1, and MLKL are responsible for the crucial event of necrosome formation;	[131,137,138,139,146,147]
RIPK1 and RIPK3 inhibitors are new therapeutic targets for RCCs;	[174]
Deregulated necroptosis triggers uncontrolled inflammatory responses and the consequent onset of human diseases.	[128]