Table 2.

Model Parameters

Description	Parameter Name	Parameter Value
Discount rate	disc	0.03
DES simulations to perform (1000s)	n	1000
Diff Eq Time step for DEQ approach	resolution	0.019
Time horizon (years) of simulation	horizon	40
Willingness to pay threshold used for NMB ($1000s / QALY)	wtp	100
Shape Parameter from Gompertz model of secular death for 40yr female fit using 2012 U.S. Social Security mortality data.	shape	0.101
Rate Parameter from Gompertz model of secular death for 40yr female fit using 2012 U.S. Social Security mortality data.	rate	0.001
Population prevalence of genetic variant.	p_g	0.2
Condition indication percentage	r_a_pct	10
Condition indication time period (years)	r_a_dur	10
Probability of ordering the genetic test.	p_o	1
Probability of death from adverse drug event.	p_bd	0.1
Adverse drug event percentage	r_b_pct	25
Adverse drug event time period (years)	r_b_dur	1
Relative risk of adverse drug event among patients with genetic variant present and alternative therapy prescribed.	rr_b	0.8
Initial cost at indication ($1000s).	c_a	10
Cost of standard drug therapy.	c_tx	0.25
Cost of pharmacogenomic alternative drug therapy.	c_alt	3
Cost of adverse drug event survival ($1000s).	c_bs	25
Cost of adverse drug event case fatality ($1000s).	c_bd	20
Cost of genetic test.	c_t	200
Disutility of developing condition.	d_a	0.05
Disutility duration (years) after developing condition.	d_at	1
Lifetime disutility of adverse drug event among survivors.	d_b	0.15

DES = Discrete Event Simulation

NMB = Net Monetary Benefit

QALY = Quality-adjusted life years