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. 2022 May 28;23(11):6078. doi: 10.3390/ijms23116078

Table 1.

List of antibodies currently in clinical development. Data were extracted from National Institutes of Health databank (https://clinicaltrials.gov/; accessed on 20 April 2022), and the Antibody Society (https://www.antibodysociety.org/covid-19-biologics-tracker/; accessed on 10 May 2022).

Antibody Company and Country Clinical Trial Stage and ID
1 REGN-COV2, a cocktail of two mAbs: REGN10987 (Imdevimab) and REGN10933 (Casirivimab) Regeneron Pharmaceuticals, Westchester County, USA Emergency Use Authorization granted in the USA; Approved in Japan, UK, EU, and Australia
2 LY-CoV555 (Bamlanivimab) and LY-CoV016 (Etesevimab) AbCellera, Vancouver, Canada and Eli Lilly, Indianapolis, USA Emergency Use Authorization granted in the USA in 2020, but limited the authorisation in 2022.
3 VIR-7831/
GSK4182136 (Sotrovimab)
Vir Biotechnology, San Francisco, USA and GSK, Middlesex, UK Emergency Use Authorization granted in the USA; Approved in Australia, UK, and EU.
4 CT-P59 (Regdanvimab) Celltrion Group, Incheon, South Korea Emergency Use Authorization granted in South Korea and EU.
5 AZD7442 (AZD8895/Tixagevimab and AZD1061/Cilgavimab) AstraZeneca, Macclesfield, UK Emergency Use Authorization granted in the USA
6 TY027 Tychan, National University of Singapore Phase 3 (NCT04429529 and NCT04649515)
7 BRII-196/ BRII-198 (Amu-barvimab/Romlusevimab) Brii Bio, Durham, USA/TSB Therapeutics/Tsinghua University, China Approved in China
Phase 3 (NCT04501978, NCT04479631, and NCT04479644)
8 ADG20 Adagio Therapeutics, Waltham, USA Phase 2/3 (NCT04805671
and NCT04859517)
9 SCTA01 Sinocelltech, China Phase 2/3 (NCT04483375 and NCT04644185)
10 C144-LS and C-135-LS Bristol-Myers Squibb, New York City, USA Phase 2/3 (NCT04700163 and Activ-2 study)
11 ADM03820 Ology Bioservices, Alachua, USA Phase 2/3 (NCT05142527)
12 REGN14256 + imdevimab Regeneron, Westchester County, USA Phase ½/3 (NCT05081388)
13 MAD0004J08 Toscana Life Sciences Sviluppo s.r.l, Siena, Italy Phase 2/3 (NCT04932850 and
NCT04952805)
14 MW33 Mabwell Bioscience Co, Zhangjiang Hi-tech Park, Shanghai Phase 2 (NCT04533048 and NCT04627584)
15 Etesevimab (JS016, LY3832479, LY-CoV016) Junshi Biosciences, China and Eli Lilly, Indianapolis, USA Phase 2 (NCT04441918,
NCT04441931, and
NCT04427501)
16 BGB-DXP593 BeiGene, Beijing, China Phase 2 (NCT04551898 and NCT04532294)
17 COVI-AMG (STI-2020) Sorrento Therapeutics, San Diego, USA Phase 2 (NCT04734860)
18 LY-CoV1404, LY3853113 AbCellera, Vancouver, Canada and Eli Lilly, Indianapolis, USA Phase 2 (NCT04634409)
19 IBIO-123 Immune Biosolutions, Sherbrooke, Canada Phase 2 (Not Available)
20 VIR-7832 Vir Biotechnology, San Francisco, USA Phase 1/2 (NCT04746183)
21 COR-101 CORAT Therapeutics, Braunschweig, Germany Phase 1/2 trial (NCT04674566)
22 DZIF-10c, BI 767551 University of Cologne, Germany Phase 1/2 (NCT04631666 and NCT04631705)
23 XVR011 Exevir Bio BV, Belgium Phase 1/2 (NCT04884295)
24 HLX70 Hengenix Biotech Inc., Milpitas, USA Phase 1 (NCT04561076)
25 DXP-604 BeiGene, Beijing, China Phase 1 (NCT04669262)
26 ZRC-3308 Zydus Cadila, Ahmedabad, India Phase 1 (Not Available)
27 HFB30132A HiFiBiO Therapeutics, Cambridge, USA Phase 1 (NCT04590430)
28 ABBV-47D11 Abbvie, North Chicago, USA Phase 1 (NCT04644120)
29 C144-LS and C-135-LS Bristol-Myers Squibb, New York City, USA Phase 1 (NCT04700163)
30 JMB2002 Jemincare Group, Shanghai Phase 1 (ChiCTR2100042150)
31 IMM-BCP-01 Immunome, Inc., Exton, USA Phase 1 (Not Available)
32 SCTA01 Sinocelltech, China Phase 1 (NCT04483375)
33 MW33 Mabwell Bioscience Co., Ltd., Shanghai Phase 1 (NCT04533048)
34 Anti-SARS-CoV-2 mAb Stanford University, Stanford, USA Phase 1 (NCT04567810)
35 P2C-1F11 Brii Biosciences, Durham, USA Phase 1 (NCT04479631 and NCT04479644)
36 SCTA01 Sinocelltech, China Phase 1 (NCT04483375)
37 LY-CovMab Luye Pharma Group, Princeton, USA Phase 1 (NCT04973735)
38 CT-P63 Celltrion Group, Incheon, South Korea Phase 1 (NCT05017168)
39 IGM-6268 IGM Biosciences, Mountain View, USA Phase 1 (NCT05160402 and NCT05184218)