Table 1.
Antibody | Company and Country | Clinical Trial Stage and ID | |
---|---|---|---|
1 | REGN-COV2, a cocktail of two mAbs: REGN10987 (Imdevimab) and REGN10933 (Casirivimab) | Regeneron Pharmaceuticals, Westchester County, USA | Emergency Use Authorization granted in the USA; Approved in Japan, UK, EU, and Australia |
2 | LY-CoV555 (Bamlanivimab) and LY-CoV016 (Etesevimab) | AbCellera, Vancouver, Canada and Eli Lilly, Indianapolis, USA | Emergency Use Authorization granted in the USA in 2020, but limited the authorisation in 2022. |
3 | VIR-7831/ GSK4182136 (Sotrovimab) |
Vir Biotechnology, San Francisco, USA and GSK, Middlesex, UK | Emergency Use Authorization granted in the USA; Approved in Australia, UK, and EU. |
4 | CT-P59 (Regdanvimab) | Celltrion Group, Incheon, South Korea | Emergency Use Authorization granted in South Korea and EU. |
5 | AZD7442 (AZD8895/Tixagevimab and AZD1061/Cilgavimab) | AstraZeneca, Macclesfield, UK | Emergency Use Authorization granted in the USA |
6 | TY027 | Tychan, National University of Singapore | Phase 3 (NCT04429529 and NCT04649515) |
7 | BRII-196/ BRII-198 (Amu-barvimab/Romlusevimab) | Brii Bio, Durham, USA/TSB Therapeutics/Tsinghua University, China | Approved in China Phase 3 (NCT04501978, NCT04479631, and NCT04479644) |
8 | ADG20 | Adagio Therapeutics, Waltham, USA | Phase 2/3 (NCT04805671 and NCT04859517) |
9 | SCTA01 | Sinocelltech, China | Phase 2/3 (NCT04483375 and NCT04644185) |
10 | C144-LS and C-135-LS | Bristol-Myers Squibb, New York City, USA | Phase 2/3 (NCT04700163 and Activ-2 study) |
11 | ADM03820 | Ology Bioservices, Alachua, USA | Phase 2/3 (NCT05142527) |
12 | REGN14256 + imdevimab | Regeneron, Westchester County, USA | Phase ½/3 (NCT05081388) |
13 | MAD0004J08 | Toscana Life Sciences Sviluppo s.r.l, Siena, Italy | Phase 2/3 (NCT04932850 and NCT04952805) |
14 | MW33 | Mabwell Bioscience Co, Zhangjiang Hi-tech Park, Shanghai | Phase 2 (NCT04533048 and NCT04627584) |
15 | Etesevimab (JS016, LY3832479, LY-CoV016) | Junshi Biosciences, China and Eli Lilly, Indianapolis, USA | Phase 2 (NCT04441918, NCT04441931, and NCT04427501) |
16 | BGB-DXP593 | BeiGene, Beijing, China | Phase 2 (NCT04551898 and NCT04532294) |
17 | COVI-AMG (STI-2020) | Sorrento Therapeutics, San Diego, USA | Phase 2 (NCT04734860) |
18 | LY-CoV1404, LY3853113 | AbCellera, Vancouver, Canada and Eli Lilly, Indianapolis, USA | Phase 2 (NCT04634409) |
19 | IBIO-123 | Immune Biosolutions, Sherbrooke, Canada | Phase 2 (Not Available) |
20 | VIR-7832 | Vir Biotechnology, San Francisco, USA | Phase 1/2 (NCT04746183) |
21 | COR-101 | CORAT Therapeutics, Braunschweig, Germany | Phase 1/2 trial (NCT04674566) |
22 | DZIF-10c, BI 767551 | University of Cologne, Germany | Phase 1/2 (NCT04631666 and NCT04631705) |
23 | XVR011 | Exevir Bio BV, Belgium | Phase 1/2 (NCT04884295) |
24 | HLX70 | Hengenix Biotech Inc., Milpitas, USA | Phase 1 (NCT04561076) |
25 | DXP-604 | BeiGene, Beijing, China | Phase 1 (NCT04669262) |
26 | ZRC-3308 | Zydus Cadila, Ahmedabad, India | Phase 1 (Not Available) |
27 | HFB30132A | HiFiBiO Therapeutics, Cambridge, USA | Phase 1 (NCT04590430) |
28 | ABBV-47D11 | Abbvie, North Chicago, USA | Phase 1 (NCT04644120) |
29 | C144-LS and C-135-LS | Bristol-Myers Squibb, New York City, USA | Phase 1 (NCT04700163) |
30 | JMB2002 | Jemincare Group, Shanghai | Phase 1 (ChiCTR2100042150) |
31 | IMM-BCP-01 | Immunome, Inc., Exton, USA | Phase 1 (Not Available) |
32 | SCTA01 | Sinocelltech, China | Phase 1 (NCT04483375) |
33 | MW33 | Mabwell Bioscience Co., Ltd., Shanghai | Phase 1 (NCT04533048) |
34 | Anti-SARS-CoV-2 mAb | Stanford University, Stanford, USA | Phase 1 (NCT04567810) |
35 | P2C-1F11 | Brii Biosciences, Durham, USA | Phase 1 (NCT04479631 and NCT04479644) |
36 | SCTA01 | Sinocelltech, China | Phase 1 (NCT04483375) |
37 | LY-CovMab | Luye Pharma Group, Princeton, USA | Phase 1 (NCT04973735) |
38 | CT-P63 | Celltrion Group, Incheon, South Korea | Phase 1 (NCT05017168) |
39 | IGM-6268 | IGM Biosciences, Mountain View, USA | Phase 1 (NCT05160402 and NCT05184218) |