Table 1.
Reactions to vaccination in children with mastocytosis (modified from 64).
| Authors | Patients with Reactions/Total Sample | Variant of Mastocytosis/Age of Diagnosis (Years) | Eliciting Vaccine (Number of Doses Received) | Reaction/Time Interval | Subsequent Vaccines/ Premedication |
|---|---|---|---|---|---|
| Zanoni et al. [66] | 7/102 (35 children) |
Mastocytoma/0.5 Mastocytoma/0.4 Mastocytoma/2 Mastocytoma/0.6 MPCM/0.2 MPCM/0.5 DCM/0.4 |
Hexavalent (1) Hexavalent (2) MenC (1) Hexavalent (3) PCV (2), MenC (1) HPV (1) Hexavalent (1,2), PCV (1, 2) |
Urticaria and angioedema/20 min Local and facial flushing/20 min Fever and gastrointestinal clinical manifestations/24 h Injection site reaction and fever/8 h Fever/8 h Hives on arm and nasal obstruction/12 h Hives and itch on trunk and febrile convulsions/12 h |
DTaP, IPV, HB, Hib, MMRV/not available Hexavalent/not available PCV/not available |
| Parente et al. [69] | 4/72 children | MPCM/0.3 Mastocytoma/2 Mastocytoma/4 DCM/0.1 |
Hexavalent (1) Hexavalent (1) Hexavalent (1) Hexavalent (1) |
Bullous skin reaction/6–12 h Diffuse urticaria/1–4 h Diffuse urticaria/1–4 h Bullous skin reaction and mild bronchospasm/6–12 h |
Other mandatory vaccines/oral antihistamines Other mandatory vaccines Other mandatory vaccines Other mandatory vaccines/oral antihistamines |
| Bankova et al. [70] | 1 child | DCM | DTaP IPV HiB Rotavirus | Confluent blisters on the back, abdomen, and upper arms/a day later | Unknown/oral and topical sodium cromolyn |
| Johansen et al. [71] | 1 child3/35 children | MPCM MPCM MPCM |
DTaP IPV HiB Rotavirus DTaP All vaccines |
Skin flushing, itch, blisters, gastrointestinal clinical manifestations/hours Skin flushing and pruritus/minutes Fever/hours |
|
| Sarcina et al. [64] | 1 child | MPCM | inactivated tetravalent influenza vaccine (2) | diffuse bullous cutaneous reaction/24 h | PCV13; V vaccines oral antihistamines and betamethasone (background therapy with ketotifen) |
DCM, diffuse cutaneous mastocytosis; Hexavalent, diphtheria–tetanus toxoid–acellular pertussis (DTaP)–hepatitis B (HB)–inactivated polio vaccine (IPV)–Haemophilus influenzae B vaccine (HiB); h, hours; HPV, human papilloma virus vaccine; IPV, inactivated polio vaccine; min, minutes; MPCM, maculopapular cutaneous mastocytosis; Men C, meningococcal C vaccine; MMRV, measles, mumps, rubella, varicella vaccine; PCV, pneumococcal vaccine.