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. 2022 May 27;23(11):6050. doi: 10.3390/ijms23116050

Figure 1.

Figure 1

A schematic of the humoral response-immunoglobulin major class switching following SARS-CoV-2 infection and COVID-19 progress is illustrated in (A). IgG predominates 3–4 weeks after the onset of symptoms and the major structural and functional domains of IgG are also illustrated. The variation in the neck region of the 4 subclasses of human IgG are shown in (B), while (C) shows structure and functional interaction regions of immunoglobulin. IgG3 is the largest and its heavy chain (Hc) resolution in MALDI-ToF mass spectra (D) is indicated at 54,000 m/z (IgG3 Hc). Also indicated is the IgG1 heavy chain (IgG1 Hc), which resolves at 51,000 m/z. The position of the IgM heavy chain peak (IgM Hc) is indicated at 74,000 m/z. An Ig (IgX Hc), which is thought to be either IgG2 or IgG4 but has yet to be fully identified, was found in patient samples, and is shown at 49,000 m/z.