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The subunit-mediated activated state. (A) State I of plasmin-activated (hα2M)4 with three compact (blue) and an expanded (yellow) subunit (Left). After the front half of the map was removed, an asymmetric, large density corresponding to plasmin becomes evident (red) (Right). (B) Analysis by symmetry expansion of native (hα2M)4 reveals arrangements with one (Top Left), two (Top Right and Bottom Left), and three (Bottom Right) compact subunits (blue).
