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Extracellular inhibition of SARS-CoV-2 Mpro/3CL and ACE2 activities by TBrC. TBrC exhibited the extracellular inhibition of activities of SARS-CoV-2 Mpro/3CL (A) and ACE2 (B) at the indicated concentrations, but T displayed no significant inhibition. The well-known small molecule inhibitors of Mpro/3CL (Ebselen) and ACE2 (MLN-4760) as the positive controls show remarkable suppression of Mpro/3CL (A) and ACE2 (B) activities.
