Figure 2.

LOXL2 expression promotes the deposition of collagen fibers in tumors: MCF-7 breast cancer derived cells were transfected with an empty expression vector or a vector directing expression of the full length cDNA encoding LOXL2. (A) The living parts of tumors derived from MCF-7 cells transfected with empty expression vector which do not suffer from excessive hypoxia contain low concentrations of collagen fibers as revealed by blue Mason’s trichrome staining (arrows). (B) In contrast, the living parts of tumors derived from MCF-7 cells expressing recombinant LOXL2 contain much higher concentrations of collagen fibers (arrows) (Pictures taken from reference [10]).