Figure 2.

Molecular characterization of PDX models based on single-nucleotide variants. (a) Comparative analysis of the total number of genes carrying SNVs in each PDX model, grouped as MSI and HCN. (b) Venn Diagram showing the number of genes with SNVs for each PDX group, MSI (blue) vs. HCN (orange) and the overlap between them. (c,d) Percentage of the most frequent types of SNV found in MSI and HCN PDX models. Others classification included all minority SNVs such as spliced donor/acceptor variant, start lost or any other alteration that did not fit with indels, missense or stop gain/loss mutations. (e) Hierarchical heatmap clustering analysis based on the frequency of genes carrying SNVs for both MSI and HCN PDX models.