Table 5.

Complications according to anticoagulant methods. RCA: regional citrate anticoagulation; RBC, red blood cells.

	Complications		p-Value	Complication
Source	RCA	Heparin
Sik et al., 2019 [15]	7.01%	6.41%	0.956	Metabolic alkalosis
	12.28%	2.56%	<0.05	Hypocalcemia
	14.03%	10.25%	<0.05	Hypernatremia
	0.8 [0.3–2.0]	1.65 [0.5–2.38]	0.32	Units of RBC transfused
Rico et al., 2017 [18]	30%	32.6%	0.605	Severe bleeding events
Raymakers-Janssen et al., 2017 [19]	3 [2.0–5.0]	6.5 [1.5–23.8]	0.12	Units of RBC transfused
Zaoral et al., 2016 [20]	0.17 [0.0–1.0]	0.36 [0.0–2.0]	0.003	Units of RBC transfused
Fernandez et al., 2014 [21]	45.5%	0%	<0.01	Hypochloremia
	27.3%	0%	0.045	Hypomagnesemia
	0%	27.8	0.06	Hypophosphatemia
Soltysiak et al., 2014 [22]	18.75%	0%	N/A	Hyponatremia
Soltysiak et al., 2014 [22]	18.75%	14.3%	N/A	Hypernatremia
	12.5%	21.4%	N/A	Hyperkalemia
	62.5%	28.6%	N/A	Hypokalemia
	43.75%	64.3%	N/A	Hypercalcemia
	43.75%	0%	N/A	Hypocalcemia
	43.75%	42.9%	N/A	Metabolic acidosis
	25%	14.3%	N/A	Metabolic alkalosis