Figure 3.

FMRP and Homeostatic Intrinsic Plasticity regulate distinct and overlapping groups of ion channels. Venn diagram of ion channels that are regulated by FMRP or HIP, and the subset that overlap (middle line). The ion channel regulation can be either at the level of mRNA or protein function. Note that the FMRP ion channel targets continue to be validated depending on cell type, age, and brain region. For other reviews on ion channels targeted by FMRP (see Darnell et al., 2011; Contractor et al., 2015; Brager and Johnston, 2014).