Figure 1.

Molecular mechanisms of tumor drug resistance induced by EGFR, PI3K/Akt, Wnt/β-catenin, TGF-β, and combinations of these signaling pathway inhibitors’ derivatives from natural products to overcome tumor resistance. (A) EGFR signaling pathway and its inhibitors’ derivatives from natural products. (B) PI3K/Akt signaling pathway and its inhibitors derivatives from natural products. (C) Wnt/β-catenin signaling pathway and its inhibitors’ derivatives from natural products. (D)TGF-β signaling pathway and its inhibitors’ derivatives from natural products. (E) Notch signaling pathway and its inhibitors’ derivatives from natural products.