Table 1.
Natural products in preventing tumor drug resistance.
| Natural Products | Molecular Structure | Cancer | Signaling Pathway |
|---|---|---|---|
| 1. Alkaloids | |||
| Matrine |
|
Lung cancer | PI3K/AKT/mTOR |
| Breast cancer | Wnt/β-catenin | ||
| Hepatocellular carcinoma | PI3K/AKT/mTOR, AKT/GSK3/β-catenin | ||
| Ovarian cancer | MAPK/ERK PI3K/AKT/mTOR |
||
| Urothelial bladder carcinoma | VEGF/PI3K/AKT | ||
| Tetrandrine |
|
Ovarian cancer | β-catenin/c-myc/cyclin D1 |
| Pancreatic cancer | PI3K/AKT/mTOR | ||
| Gastric cancer | AKT/mTOR | ||
| Bladder cancer | AMPK/mTOR | ||
| Neferine |
|
Ovarian cancer | mTOR/p70S6K, MAPK/JNK |
| Lung cancer | PI3K/AKT/mTOR | ||
| Dauricine |
|
Renal cell carcinoma | Cell cycle |
| Melanoma | Src/STAT3 | ||
| Hepatic cell carcinoma | miR-199aHK2/PKM2 | ||
| Cepharanthine |
|
Breast cancer | Akt/mTOR |
| Ovarian cancer | PI3K/AKT | ||
| Solanine |
|
Endometrial cancer | PI3K/AKT |
| 2. Flavonoid | |||
| Meletin |
|
Prostate cancer | PI3K/AKT |
| Colon cancer | Notch-1 | ||
| Curcumin |
|
Hepatocellular carcinoma | PI3K/AKT/mTOR |
| Lung cancer | PI3K/AKT | ||
| Colorectal cancer | TGF-β/Smad2/3 | ||
| 3.Terpene | |||
| Ginsenoside |
|
Gastric cancer | PI3K/AKT/mTOR |
| Glioblastoma | Wnt/β-catenin | ||
| Soil bastard saponin |
|
Colorectal cancer | Wnt/β-catenin signaling pathway |