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. 2022 May 26;13:840719. doi: 10.3389/fimmu.2022.840719

Figure 2.

Figure 2

IL-38 deficiency aggravates DSS colitis. (A) DAI scores of WT and IL-38 deficient mice [indicated as knock-out (KO) mice]. Mice were subjected to DSS or H2O only. Maximum DAI is 121. N = 11 for H2O, 14 for DSS. (B) Weight loss of WT and IL-38 KO mice subjected to DSS versus H2O only. Maximum loss is 20%. N = 11 for H2O, N = 14 for DSS. (C) Colon length to body mass ratios of WT and IL-38 KO mice subjected to DSS versus H2O only. N = 8-9. (D) Serum FITC-dextran in WT and IL-38 KO mice subjected to DSS versus H2O (n = 6-7). (E) Histological scoring of colon tissue of WT and IL-38 KO mice subjected to DSS versus H2O. Maximum histological score 40 (n = 6). (F-I) Representative H&E stained histological slide of colon tissue of WT mice subjected to H2O (F) or DSS (G), and IL-38 deficient mice subjected to H2O (H) and DSS (I). Data were pooled from 2-3 separate experiments. The data represents the mean ± SEM, #P < 0.1, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by two-way ANOVA with Fisher’s multiple comparison. N.d., Not detectable; ns, not significant.