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. 2022 Jun 9;54(6):738–745. doi: 10.1016/j.pathol.2022.03.006

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© 2022 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Neuroinflammation in fatal COVID-19 patients. (A) Microglial nodule in PT10 (H&E). (B) Area of hippocampal cortical destruction by a microglial reaction in PT10 (H&E). (C) Double staining highlighting microglial activated cells (CD68-positive in pink) and scattered T cytotoxic lymphocytes (CD8-positive in brown). (D) Double staining (CD68-positive in pink and CD8-positive in brown) of a microglial nodule highlighting the presence of numerous macrophages with interspersed lymphocytes.