Table 1.

Summary of clinical and neuropathological data

Patient	Sex	Age	ID	LH	ICU	Relevant comorbidities	Neurological diagnosis	Sepsis	BW (g)	AHID	Subacute lacunar infarct	Microglial nodules	Ath	Other relevant histological findings
PT1	Male	80	13	8	0	HTN, AF, COPD	ACS	No	1245	Yes (mild)	No	No	Yes
PT2	Female	83	14	3	0	Degenerative dementia	ACS	No	1055	No	No	No	Yes	Pathological features of Alzheimer's disease NIA-AA (A2, B2, C2)
PT3	Male	58	16	12	12	DM2	Severe encephalopathy of unknown cause	No	1490	Yes (global)	No	No	Yes
PT4	Male	69	19	18	17	HTN, DM2, ischaemic cardiopathy, CKD	Not available	Yes	1280	No	No	No	Yes
PT5	Male	69	25	22	22	Ischaemic cardiopathy	Encephalopathy attributed to sepsis and uraemia; probable CIP	Yes	1325	No	Yes	No	Yes
PT6	Female	60	32	29	19	No	Not available	Yes	1075	Yes (global)	No	No	Yes	Frontal subarachnoid haemorrhage
PT7	Male	73	34	26	25	No	Severe encephalopathy, probably anoxic	No	1195	No	Yes	Yes	Yes
PT8	Male	70	36	32	30	No	Not available	Yes	1450	No	No	Yes	Yes
PT9	Male	55	40	33	19	DM2, DL	Probable CIP	No	1290	No	No	Yes	No	Subacute pituitary infarcts
PT10	Male	63	45	37	36	Mitral prosthetic valve Staphylocccus aureus endocarditis	Severe encephalopathy of unknown cause	Yes	1270	No	Yes	Yes	No
PT11	Male	52	57	50	50	HTN	Confirmed CIM	Yes	1150	No	Yes	No	Yes
PT12	Male	73	74	69	49	DL	Not available	Yes	1345	No	No	No	Yes
PT13	Male	62	108	102	95	DL	Mild encephalopathy; probable CIP	Yes	1400	Yes (mild)	Yes	No	Yes

ACS, acute confusional state; AF, atril fibrillation; AHID, acute hypoxic-ischaemic damage; Ath, atherosclerosis; BW, brain weight; CIM, critical illness myopathy; CIP, critical illness polyneuropathy; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; DM2, Type 2 diabetes mellitus; DL, dyslipidaemia; HTN, hypertension; ICU, length of ICU stay; ID, illness duration; LH, length of hospitalisation; NIA-AA, National Institute on Aging and Alzheimer's Association.