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. 2022 Jun 9;17(6):e0269105. doi: 10.1371/journal.pone.0269105

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© 2022 Bohlin et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — Panel A shows the association between autosomal CpGs, linked to SARS-CoV-2 host genes/severe COVID-19, and predicted sex (vertical axis). Panel B shows the association between CpGs predicting age (vertical axis) and given age (horizontal axis). The distributions of the variance explained parameter R², stemming from 1,000 randomizations of genome-wide randomly selected CpGs against sex and age, are shown in Panels C and D, respectively. The vertical dashed line designates the corresponding R² for the sex (R² = 0.77, p = 0.09) and age (R² = 0.36, p = 0.04) regression models depicted in panels A and B.