Table 2. SARS-CoV-2 genes associated with host cell entry and severe COVID-19.
Source | Gene | Sex associated | Age associated | CpGs linked to gene | Chromosome |
---|---|---|---|---|---|
ACE2 Cluster [12] | ACE2* | 12 | 0 | 15 | X |
AGT | 0 | 1 | 13 | 1 | |
AGTR1 | 6 | 12 | 29 | 3 | |
AGTR2* | 5 | 0 | 5 | X | |
DPP4 | 6 | 7 | 36 | 2 | |
MEP1A | 5 | 1 | 12 | 6 | |
MEP1B | 2 | 1 | 3 | 18 | |
MME | 2 | 16 | 35 | 3 | |
PRCP | 9 | 1 | 38 | 11 | |
REN | 2 | 1 | 13 | 1 | |
XPNPEP2* | 17 | 0 | 18 | X | |
TMPRSS2 Cluster [12] | TMPRSS2 | 1 | 7 | 32 | 21 |
AR* | 47 | 0 | 47 | X | |
ERG | 16 | 15 | 78 | 21 | |
ETV1 | 10 | 6 | 45 | 7 | |
ETV4 | 0 | 5 | 32 | 17 | |
FAM3B | 1 | 7 | 18 | 21 | |
FKBP5 | 9 | 5 | 49 | 6 | |
NKX3-1 | 2 | 4 | 15 | 8 | |
PTEN | 14 | 2 | 76 | 10 | |
SLC45A3 | 6 | 4 | 34 | 1 | |
TMPRSS4 | 3 | 10 | 44 | 11 | |
GWAS [1] | ABO | 0 | 2 | 18 | 9 |
Entry [14] | ADAM17 | 8 | 0 | 33 | 2 |
GWAS [11] | CCHCR1 | 5 | 2 | 59 | 6 |
GWAS [1] | CCR9 | 1 | 4 | 15 | 3 |
Entry (late pathway) [3] | CTSB | 6 | 4 | 38 | 8 |
Entry (late pathway) [3] | CTSL | 0 | 3 | 5 | 9 |
GWAS [1] | CXCR6 | 2 | 1 | 14 | 3 |
GWAS [11] | DPP9 | 5 | 1 | 52 | 19 |
Entry (early pathway) [3] | FURIN | 7 | 5 | 47 | 15 |
GWAS [1] | FYCO1 | 5 | 4 | 38 | 3 |
GWAS [11] | HLA-G | 6 | 8 | 18 | 6 |
Entry [13] | HMGB1 | 5 | 2 | 22 | 13 |
GWAS [1] | IFNAR2 | 2 | 1 | 29 | 21 |
GWAS [1,11] | LZTFL1 | 6 | 7 | 40 | 3 |
GWAS [11] | NOTCH4 | 18 | 38 | 139 | 6 |
Entry [4] | NRP1 | 13 | 14 | 79 | 10 |
Entry [4] | NRP2 | 4 | 19 | 85 | 2 |
GWAS [11] | OAS1 | 5 | 2 | 15 | 12 |
GWAS [11] | OAS2 | 1 | 1 | 23 | 12 |
GWAS [11] | OAS3 | 3 | 0 | 21 | 12 |
GWAS [1] | SLC6A20 | 1 | 7 | 39 | 3 |
GWAS [11] | TYK2 | 2 | 1 | 46 | 19 |
GWAS [1] | XCR1 | 1 | 0 | 10 | 3 |
Total | 45 | 281 (200 without X chromosome genes) | 231 | 1572 (1487 on autosomes + 85 on X chromosome) |
‘*’ Gene located on X chromosome.