Table 2. SARS-CoV-2 genes associated with host cell entry and severe COVID-19.
The table shows information regarding genes associated with SARS-CoV-2 host cell entry as well as severe COVID-19. Source describes the source justifying the inclusion of the gene, Gene identifier refers to the gene symbol, Sex associated shows number of DMPs significantly associated with sex (pFDR<0.01), Age associated shows the same for age, CpGs linked to gene indicates the number of CpGs on the EPIC array linked to that particular gene and, finally, the last column Chromosome displays the chromosome number on which the gene is located.
| Source | Gene | Sex associated | Age associated | CpGs linked to gene | Chromosome |
|---|---|---|---|---|---|
| ACE2 Cluster [12] | ACE2* | 12 | 0 | 15 | X |
| AGT | 0 | 1 | 13 | 1 | |
| AGTR1 | 6 | 12 | 29 | 3 | |
| AGTR2* | 5 | 0 | 5 | X | |
| DPP4 | 6 | 7 | 36 | 2 | |
| MEP1A | 5 | 1 | 12 | 6 | |
| MEP1B | 2 | 1 | 3 | 18 | |
| MME | 2 | 16 | 35 | 3 | |
| PRCP | 9 | 1 | 38 | 11 | |
| REN | 2 | 1 | 13 | 1 | |
| XPNPEP2* | 17 | 0 | 18 | X | |
| TMPRSS2 Cluster [12] | TMPRSS2 | 1 | 7 | 32 | 21 |
| AR* | 47 | 0 | 47 | X | |
| ERG | 16 | 15 | 78 | 21 | |
| ETV1 | 10 | 6 | 45 | 7 | |
| ETV4 | 0 | 5 | 32 | 17 | |
| FAM3B | 1 | 7 | 18 | 21 | |
| FKBP5 | 9 | 5 | 49 | 6 | |
| NKX3-1 | 2 | 4 | 15 | 8 | |
| PTEN | 14 | 2 | 76 | 10 | |
| SLC45A3 | 6 | 4 | 34 | 1 | |
| TMPRSS4 | 3 | 10 | 44 | 11 | |
| GWAS [1] | ABO | 0 | 2 | 18 | 9 |
| Entry [14] | ADAM17 | 8 | 0 | 33 | 2 |
| GWAS [11] | CCHCR1 | 5 | 2 | 59 | 6 |
| GWAS [1] | CCR9 | 1 | 4 | 15 | 3 |
| Entry (late pathway) [3] | CTSB | 6 | 4 | 38 | 8 |
| Entry (late pathway) [3] | CTSL | 0 | 3 | 5 | 9 |
| GWAS [1] | CXCR6 | 2 | 1 | 14 | 3 |
| GWAS [11] | DPP9 | 5 | 1 | 52 | 19 |
| Entry (early pathway) [3] | FURIN | 7 | 5 | 47 | 15 |
| GWAS [1] | FYCO1 | 5 | 4 | 38 | 3 |
| GWAS [11] | HLA-G | 6 | 8 | 18 | 6 |
| Entry [13] | HMGB1 | 5 | 2 | 22 | 13 |
| GWAS [1] | IFNAR2 | 2 | 1 | 29 | 21 |
| GWAS [1,11] | LZTFL1 | 6 | 7 | 40 | 3 |
| GWAS [11] | NOTCH4 | 18 | 38 | 139 | 6 |
| Entry [4] | NRP1 | 13 | 14 | 79 | 10 |
| Entry [4] | NRP2 | 4 | 19 | 85 | 2 |
| GWAS [11] | OAS1 | 5 | 2 | 15 | 12 |
| GWAS [11] | OAS2 | 1 | 1 | 23 | 12 |
| GWAS [11] | OAS3 | 3 | 0 | 21 | 12 |
| GWAS [1] | SLC6A20 | 1 | 7 | 39 | 3 |
| GWAS [11] | TYK2 | 2 | 1 | 46 | 19 |
| GWAS [1] | XCR1 | 1 | 0 | 10 | 3 |
| Total | 45 | 281 (200 without X chromosome genes) | 231 | 1572 (1487 on autosomes + 85 on X chromosome) | |
‘*’ Gene located on X chromosome.