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. 2022 May 27;16(5):e0010433. doi: 10.1371/journal.pntd.0010433

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© 2022 Woolsey et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — MARV antigen (red) IHC positivity in sinusoidal lining cells and Kupffer cells of the liver for the positive control (Control 1) (A), group day -5 vaccinated fatal subject (Fatal 1) euthanized 9 DPI (E), group day -3 vaccinated fatal subject (Fatal 4) euthanized 7 DPI (I). IHC positive mononuclear cells within the red and white pulp of the spleen for the positive control (Control 1) (B), group day -5 vaccinated fatal subject (Fatal 1) euthanized 9 DPI (F), group day -3 vaccinated fatal subject (Fatal 4) euthanized 7 DPI (J). No appreciable immunolabeling of the liver or spleen for macaques that survived from group day -7 (Survivor 1) (C, D), group day -5 (Survivor 7) (E), or group day -3 (Survivor 10) (I). All representative liver sections were taken at 20x magnification, and all spleen sections were taken at 10x magnification. IHC, immunohistochemistry; MARV, Marburg virus; DPI, days post infection.