Table 4.
Effect of compounds (3b, 3c, 3d, 3e, 3f, 4b, 4c, 4d and 4e) in rats in the ″open field″ test.
| Compounds | Dose, mg/kg |
Amount (Absolute Data over 5 min) * | ||
|---|---|---|---|---|
| Horizontal Displacement |
Vertical Displacement |
Cells | ||
| Control | – | 25.8 ± 3.5 | 6.1 ± 1.1 | 0.5 ± 0.02 |
| 3b | 50 | 26.4 ± 3.6 | 3.3 ± 0.6 ** | 2.6 ± 0.6 ** |
| 3c | 50 | 42.6 ± 6.3 ** | 6.8 ± 1.2 | 1.2 ± 0.06 ** |
| 3d | 50 | 44.8 ± 5.2 ** | 9.6 ± 1.9 ** | 2.8 ± 0.5 ** |
| 3e | 50 | 24.4 ± 3.7 | 2.8 ± 0.7 ** | 2.8 ± 0.53 ** |
| 3f | 50 | 58.2 ± 6.1 ** | 7.0 ± 2.2 | 2.4 ± 0.8 ** |
| 4b | 50 | 40.4 ± 7.5 ** | 4.5± 0.9 | 0.9 ± 0.05 ** |
| 4c | 50 | 43.8 ± 4.1 ** | 6.2 ± 1.8 | 2.2 ± 0.6 ** |
| 4d | 50 | 34.2 ± 4.8 ** | 5.2 ± 0.7 | 2.2 ± 0.3 ** |
| 4e | 50 | 50.4 ± 7.3 ** | 7.1 ± 3.0 | 2.5 ± 0.7 ** |
| Ethosuximide | 200 | 26.8 ± 3.8 | 5.8 ± 1.9 | 0.6 ± 0.08 |
| Diazepam | 2 | 33.6 ± 4.2 ** | 6.4 ± 1.0 | 3.2 ± 0.9 ** |
* p ≤ 0.05 at a probability level, ** The differences are statistically significant compared to the control.