Table 1.
Proteins that significantly changed in content following aflibercept intervention.
| Protein IDs | Protein Name | Gene Name | p-Value | Fold Change Aflibercept/NaCl |
|---|---|---|---|---|
| P17948 | Vascular endothelial growth factor receptor 1 * | FLT1 | p < 0.001 | 46.42 |
| P0DOX5;P01857 | Ig gamma-1 chain C region ** | IGHG1 | p < 0.001 | 18.90 |
| P35968 | Vascular endothelial growth factor receptor 2 *** | KDR | p < 0.001 | 5.07 |
| O43823 | A-kinase anchor protein 8 | AKAP8 | 0.027 | 1.19 |
| O60831 | PRA1 family protein 2 | PRAF2 | 0.039 | 0.91 |
| Q29092;P14625 | Endoplasmin | HSP90B1 | 0.041 | 0.91 |
| Q9NR30-2;Q9NR30 | Nucleolar RNA helicase 2 | DDX21 | 0.046 | 0.90 |
| O15258 | Protein RER1 | RER1 | 0.0091 | 0.90 |
| O60518 | Ran-binding protein 6 | RANBP6 | 0.030 | 0.90 |
| Q99615 | DnaJ homolog subfamily C member 7 | DNAJC7 | 0.0057 | 0.89 |
| Q92522 | Histone H1x | H1FX | 0.046 | 0.88 |
| Q9HCM4 | Band 4.1-like protein 5 | EPB41L5 | 0.033 | 0.88 |
| Q9HCS7 | Pre-mRNA-splicing factor SYF1 | XAB2 | 0.019 | 0.87 |
| Q53SF7 | Cordon-bleu protein-like 1 | COBLL1 | 0.036 | 0.87 |
| P86791;P86790 | Vacuolar fusion protein CCZ1 homolog; Vacuolar fusion protein CCZ1 homolog B |
CCZ1;CCZ1B | 0.029 | 0.87 |
| Q9NP97 | Dynein light chain roadblock-type 1 | DYNLRB1 | 0.027 | 0.85 |
| P36955 | Pigment epithelium-derived factor (PEDF) | SERPINF1 | 0.020 | 0.84 |
| Q5VZL5 | Zinc finger MYM-type protein 4 | ZMYM4 | 0.030 | 0.83 |
| P83916 | Chromobox protein homolog 1 | CBX1 | 0.046 | 0.82 |
| P62272;P62269 | 40S ribosomal protein S18 | RPS18 | 0.030 | 0.76 |
| Q9Y2R9 | 28S ribosomal protein S7, mitochondrial | MRPS7 | 0.026 | 0.70 |
* VEGFR-1 immunoglobulin domain of aflibercept. ** Ig gamma-1 chain C region of the aflibercept fusion protein. *** VEGFR-2 immunoglobulin domain of aflibercept. p-values refer to p-values from Student’s t-test used to identify significantly changed proteins.