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. 2022 May 25;27(11):3412. doi: 10.3390/molecules27113412

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Natural products regulate the modulation of the Notch signaling pathway in BC. The Notch receptor is cleaved by Notch ligands, including Jagged-1. ADAM-10 initially cleaves the Notch extracellular domain; the gamma–secretase complex then cleaves the Notch intracellular domain (NICD). NICD moves into the nucleus and initiates transcription. MAML: mastermind-like protein; EGCG: epigallocatechin-3-gallate; RBP-Jκ: recombinant signal binding protein for immunoglobulin kappa J region; DATS: diallyl trisulfide; ADAM-10: a disintegrin and metalloproteinase domain-containing protein 10; NICD: Notch receptor intracellular domain. This figure is reproduced from Kiesel et al. [87] (Creative Commons Attribution License (CC BY 4.0)).