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. 2022 May 25;27(11):3412. doi: 10.3390/molecules27113412

Figure 8.

Figure 8

The synergistic effect of CUR and BBR against BC cells by inducing apoptosis. Apoptosis in BC cells is induced by a combination of CUR and BBR, mediated through the activation of the ERK signaling pathway. These two compounds work together to enhance JNK activation, phosphorylation of Bcl-2, and dissociation of the Beclin1/Bcl-2 complex in BC cells, eventually resulting in autophagic cell death. Bcl-2: B-cell lymphoma 2; Bax: BCL2-associated X protein; PARP: poly (ADP-ribose) polymerase; JNK: c-Jun N-terminal kinase; ERK: extracellular signal-regulated kinase. This figure is reproduced from Wang et al. [104] (Creative Commons Attribution License (CC BY 4.0)).