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Evaluation of CM-398 for acute thermal antinociception in the 55 °C warm water tail-withdrawal assay. Mean ± SEM of latency to withdraw the tail from warm water after treatment with morphine (10 mg/kg, i.p.; red circles), CM-398 (30 mg/kg, i.p.; cyan triangles), or vehicle (0.9% saline, i.p.; gray diamonds) was examined every 10 min up to 110 min.; n = 7–8 for all points, * p < 0.05; two-way RM ANOVA with Tukey’s post hoc test.
